A Review on the Some Biological Activities of the Hydantoin Derivatives

Hydantoin derivatives are commonly used anticonvulsants. In general, they effective for partial-onset seizures and tonic-clonic seizures, but not absence seizures. Phenytoin is the most important drug in this group, other drugs, ethotoin, mephenytoin, also to treat epilepsy. Prodrugs such as have been created. some cases of trigeminal neuralgia related neuralgia. arrhythmias. Hydantoins or glycolylureas heterocyclic organic compounds with formula CH2C(O)NHC(O)NH. It a colorless solid formed by reaction glycolic acid urea. an oxidized derivative imidazolidine. more general sense, hydantoins can refer groups classes that share same ring structure their parent. For example, phenytoin (see below) has two phenyl substituted at 5th carbon hydantoin molecule. Actual chemotherapy epilepsy dates back 1850s when "inorganic bromides" were introduced. However, it worth noting around 1920s, therapeutic beneficial use 'phenobarbital' usheredin era meaningful treatment chemistry synthesis rings various methods applications medical field. Previous descriptions hydantoin-containing broad pharmacological biological activities, including anticancer, anti-inflammatory, anti-immune, antimetabolite, antioxidant, antibacterial, CNS-related, anticonvulsant, antitussive, cytoprotective activities.
 Keywords: derivatives, anticonvulsants,